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Bone HealthBone Health

Osteoporosis makes bone weaker and more likely to fracture, and several different medicine types are used to slow bone loss or help maintain bone density. Which one suits a person depends on their fracture risk and the reasons treatment is being started.

Fosamax

Alendronic Acid

35mg · 70mg

Intended to relieve bone mass depletion to support mineral density and target fracture-prone skeletal areas.

From$1.52/ tabletView

Estrace

Estradiol

1mg · 2mg

Indicated to address postmenopausal hormone depletion to relieve hot flashes and support structural bone mineral density.

From$1.45/ tabletView

Evista

Raloxifene

60mg

Developed to mitigate postmenopausal bone density loss to support skeletal matrix strength and target breast tissue safety.

From$0.80/ tabletView

Actonel

Risedronate

35mg

Developed to mitigate bone loss to support bone mineral density and alleviate fracture risk.

From$5.58/ tabletView

Premarin

Conjugated Estrogens

0.625mg

Indicated to address hormone depletion to relieve hot flashes and support structural bone mineral density.

From$5.04/ tabletView

Melatonin Tablets

Melatonin

3mg

Indicated to address sleep cycle disturbances to manage circadian rhythm and support natural skeletal hormone levels.

From$1.01/ tabletView

Didronel

Etidronate

200mg

Utilised to manage abnormal bone turnover to alleviate skeletal pain and support structural bone preservation.

From$1.21/ tabletView

Fortical

Calcitonin Salmon

200iu

Slow bone loss at the spine in postmenopausal osteoporosis to help increase bone mineral density

From$191.25/ sprayView

Key points

  • NHS lists bisphosphonates among the medicines most commonly used for osteoporosis.
  • NIAMS notes that bone density testing and fracture risk help guide osteoporosis treatment decisions.
  • Hormone-related medicines can help prevent osteoporosis in women after the menopause, alongside their primary use for menopausal symptoms.

Bisphosphonates: the main osteoporosis medicines

Fosamax contains alendronic acid, Actonel contains risedronate and Didronel contains etidronate; all three are used for osteoporosis or for Paget’s disease of bone, a condition of abnormal bone remodelling. NHS lists bisphosphonates among osteoporosis treatments in Osteoporosis - Treatment.

Other medicines used specifically for osteoporosis

Evista contains raloxifene, used to prevent postmenopausal osteoporosis and, separately, to reduce breast cancer risk. Fortical contains calcitonin salmon and is taken as a nasal spray rather than a tablet, used for postmenopausal osteoporosis. NIAMS discusses these alongside bisphosphonates in Osteoporosis: Diagnosis, Treatment, and Steps to Take.

Hormone therapy and bone protection

Premarin contains conjugated estrogens and Estrace contains estradiol; both treat menopausal vasomotor symptoms, and Estrace also treats atrophic vaginitis, while each also helps prevent postmenopausal osteoporosis.

Melatonin Tablets also appears in this group. It contains melatonin and is used for circadian rhythm sleep disorders, unrelated to bone health.

Further reading