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Azathioprine

Azathioprine is a thiopurine immunosuppressant. Its metabolites interfere with purine synthesis, reducing proliferation of immune cells.

Imuran

Rheumatoid Arthritis

25mg · 50mg

Utilised to manage chronic immune hyperactivity to alleviate joint tissue damage and support organ transplant viability.

From$1.55/ tabletView

Key points

  • Azathioprine suppresses immune-cell proliferation through thiopurine metabolites.
  • Blood-count and liver monitoring are central to its safety profile.

Imuran connects azathioprine with rheumatoid arthritis and renal-transplant rejection prophylaxis in autoimmune support. Bone-marrow suppression, infection and malignancy risks make the monitoring context central to this ingredient page and require qualified clinical review.

Boxed warning

Azathioprine’s label carries a boxed warning for malignancy. Chronic immunosuppression with azathioprine, a purine antimetabolite, increases the risk of malignancy in humans, including reported post-transplant lymphoma and hepatosplenic T-cell lymphoma in patients with inflammatory bowel disease.

Further reading