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Desmopressin

Desmopressin (Nocdurna) is used as antidiuretic replacement therapy for central diabetes insipidus. This listing includes Ddavp Spray and Nocdurna, which are also listed for nocturnal enuresis or nocturia.

Ddavp Spray

Central Diabetes Insipidus, Nocturnal Enuresis

10mcg 2.5ml

Desmopressin nasal spray for bedwetting and diabetes insipidus. It helps the body hold onto water.

From$70.13/ sprayView

Nocdurna

Nocturia, Nocturnal Enuresis

0.2mg

Desmopressin orodispersible tablets for nocturia and bedwetting. It mimics a hormone that makes the kidneys produce less urine at night.

From$122.30/ sprayView

Key points

  • Hyponatraemia can develop if you take in more fluid than needed while desmopressin reduces urine output, and the label says it can be fatal unless properly diagnosed and treated.
  • Nasal absorption may be unreliable when the lining of the nose has scarring, swelling, blockage or other abnormalities.
  • Kidney function affects how long desmopressin stays in the body, with the reported terminal half-life increasing from 2.8 hours to 8.7 hours in severe renal impairment.

How Desmopressin works

Desmopressin acetate, also called DDAVP, acts like the body’s natural hormone that manages water balance. It tells the kidneys to return more water to the body, reducing urine production. This supports its use in Central Diabetes Insipidus.

Further reading