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Naltrexone

Naltrexone (Revia) is an opioid antagonist listed for alcohol dependence and opioid dependence. This catalogue lists it as Revia, Naltrexone Tablets and a low-dose capsule, plus the Mysimba combination with bupropion for weight management.

Low Dose Naltrexone Capsules

Fibromyalgia

1.5mg

Naltrexone capsules for fibromyalgia and fatigue in multiple sclerosis. This low dose is far below the addiction-treatment amount.

From$2.13/ capsuleView

Mysimba

Chronic Weight Management

90mg + 8mg

Naltrexone and bupropion tablets for weight management. They work on the brain's reward system to cut food cravings.

From$2.89/ tabletView

Revia

Alcohol Dependence, Opioid Dependence

50mg

Naltrexone tablets for alcohol and opioid dependence. They block the reward effects of these substances, reducing craving.

From$3.84/ tabletView

Naltrexone Tablets

Alcohol Dependence, Opioid Dependence

50mg

Naltrexone tablets for alcohol and opioid dependence. It blocks the rewarding effects of these substances to reduce the urge to drink or use.

From$6.72/ tabletView

Key points

  • Naltrexone is an opioid antagonist, used to treat alcohol dependence and to block the effects of opioids taken from outside the body.
  • Revia and Naltrexone Tablets are single-ingredient 50mg tablets, while the low-dose capsule contains a smaller 1.5mg strength of naltrexone alone.
  • Because naltrexone blocks opioid receptors, an opioid-free interval of at least 7 to 10 days is recommended before starting it, extending to two weeks for people switching from buprenorphine or methadone.

What Naltrexone is used for

Revia and Naltrexone Tablets are listed for Alcohol Dependence and for Opioid Dependence, where naltrexone blocks the effects of opioids taken from outside the body. Mysimba, which pairs naltrexone with bupropion, has a separate on-label use: weight management in adults who meet a body-mass-index threshold, alongside a reduced-calorie diet and increased physical activity. The low-dose capsule in this catalogue is separately listed against fibromyalgia and multiple sclerosis-associated fatigue.

Common questions about Naltrexone

Why are there several brands of naltrexone in this catalogue?

Revia’s originator is DuPont Pharmaceuticals, while Naltrexone Tablets is an unbranded generic version of the same tablet; both sit in this catalogue’s Addiction Recovery category. Mysimba, whose originator is Orexigen Therapeutics, pairs naltrexone with bupropion for weight management rather than dependence, and in the UAE this combination is also listed under the brand name Contrave.

The naltrexone label notes cases of hepatitis and clinically significant liver problems during clinical trials and after the medicine’s launch. It advises seeking medical attention and stopping naltrexone if symptoms of acute hepatitis appear.

Does Mysimba carry any extra safety warnings because of the bupropion component?

Because Mysimba contains bupropion, its label links the combination to a higher rate of suicidal thinking and behaviour seen in younger patients during trials, and notes that suicidal thoughts have been reported in patients of all ages since launch. It calls for close supervision, especially early in treatment and after dose changes.

Further reading