Donamem
Donepezil and memantine tablets for Alzheimer's disease. They target two different processes in the illness.
Donamem details
- Conditions
- Alzheimer's Disease · Dementia
- Alternative names
- donepezil, memantine
- Therapeutic class
- Cholinesterase Inhibitor, NMDA Receptor Antagonist Combination
- Pharmacological class
- Alzheimer's Disease Therapy
- Contraindications
- severe hepatic impairment; hypersensitivity to any component
- Minor side effects
- diarrhoea; nausea; dizziness
- Moderate side effects
- headache; insomnia; confusion
- Serious side effects
- severe bradycardia, requires immediate medical attention
- Dosage forms
- Tablet
- Administration route
- Oral use
- Supply category
- Prescription-only medicine (POM)
- Manufacturer
- Sun Pharma
- Onset Time
- 2–4 weeks
- Duration
- 24 hours
- Storage instructions
- Store below 25°C.
- Drug interactions
- Amantadine; NSAIDs; Ketoconazole
- Age restrictions
- Approved for adults.
Patient summary
Donepezil and memantine tablets for Alzheimer's disease. They target two different processes in the illness.
Mechanism of action
Combines donepezil to increase synaptic acetylcholine with memantine to regulate glutamate activity and prevent excitotoxic injury.
Pregnancy and breastfeeding
Pregnancy: Use if potential benefit outweighs risk. Breastfeeding: Consult a doctor.