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Stendra (Avanafil) Buyer and Patient Handbook in UAE

What is Stendra?

Stendra ($\textAvanafil$) is a phosphodiesterase type 5 ($\textPDE5$) inhibitor medication used in the treatment of Erectile Dysfunction ($\textED$). This medication helps achieve and maintain an erection sufficient for sexual performance by enhancing the blood flow into the penis following sexual stimulation. It is approved for use by adult males experiencing difficulties achieving adequate rigidity. Stendra is available in the pill form.

Who Should Use Stendra?

This medication is suitable for adult men presenting with consistent difficulty achieving or sustaining an erection suitable for sexual activity.

• Adult males (18 years and older).
• Individuals seeking a treatment option specifically for erectile difficulties.
• Men who have been advised by a healthcare professional regarding the use of $\textPDE5$ inhibitors.

How Does It Work?

The mechanism of action for Stendra centres on relaxing your vascular smooth muscle. Stendra selectively inhibits the enzyme phosphodiesterase type 5 ($\textPDE5$), which is primarily active in the corpus cavernosum of the penis. Normally, during sexual arousal, nitric oxide ($\textNO$) is released, which produces cyclic guanosine monophosphate ($\textcGMP$), causing local vasodilatation (widening of blood vessels). The $\textPDE5$ enzyme typically breaks down this $\textcGMP$, curtailing the erection. Stendra prevents this breakdown, allowing $\textcGMP$ concentrations to remain higher for longer, resulting in prolonged relaxation of the arteries and increased penile blood inflow. Achieving an erection still requires adequate sexual stimulation, as the drug does not work automatically.

Stendra’s impact on daytime alertness is generally manageable for routine activities. Most users find that they can safely drive and operate machinery once they understand how the medication affects them personally. However, if you experience dizziness or vision changes, you must refrain from driving until those effects subside. Regarding recreational contexts, the potential for misuse exists, primarily by individuals without a diagnosed condition. Using Stendra when you do not need it offers no sexual performance enhancement and significantly increases the risk of adverse effects, including dangerously low blood pressure.

Why Choose Stendra?

Stendra offers a distinct pharmacokinetic profile that may be advantageous for some users. Because it acts relatively quickly, some individuals prefer it for its predictable onset timing when planning sexual activity. For those managing other health conditions, the specific metabolic pathway of Avanafil may be preferable to other PDE5 inhibitors.

While this is the branded formulation, generic Avanafil is bioequivalent, meaning it contains the same active ingredient and works the same way in the body, often at a more accessible cost. Off-label uses of Avanafil exist, such as for potentially managing certain pulmonary vascular conditions, but these applications require specific medical guidance and oversight.

Dosage, Administration, Lifestyle and Dietary Recommendations

Recommended Dosage

The typical starting dosage range for Stendra includes 50mg, 100mg, or 200mg per single use. Your healthcare provider will determine the most appropriate starting dose based on your overall health status and tolerability. The maximum recommended frequency is once per day.

How to Take

Administer the pill orally using adequate water. Stendra can be taken whether or not you have eaten a meal; however, a high-fat meal may delay the onset of the drug’s effect. Plan to take the medication approximately 15 to 30 minutes before planned intimacy.

Missed Dose

If you take Stendra and do not engage in sexual activity, or if you forget to take it when planning, simply wait until the next potential opportunity. Since this medication is taken as needed rather than on a strict schedule, there is no defined dose to "catch up" on.

Overdose or Double Dose

In the event of accidentally taking substantially more than the prescribed single dose, seek immediate medical advice or emergency support. Symptoms of overdose may include severe headaches, visual disturbances, or a prolonged, painful erection (priapism).

Special Populations

Adjustments to the standard dosage may be necessary for certain populations. The elderly population may require a lower starting dose due to potential differences in metabolism or the presence of co-morbidities. While generally not recommended for use in children, safety and efficacy profiles in younger users have not been established. Patients with severe hepatic (liver) or renal (kidney) impairment require careful dose titration, usually starting at the lowest available dose.

Lifestyle & Diet

Certain substances or foods can significantly alter the effects of Stendra. Avoid excessive consumption of alcohol near the time of dosing, as this can increase the risk of hypotension (low blood pressure) and dizziness. Furthermore, while less common than with other PDE5 medication, consult your physician regarding the intake of grapefruit or grapefruit juice, as it may inhibit the metabolism of Avanafil, resulting in higher drug levels in your system.

Precautions and Warnings

Before initiating Stendra, it is essential to inform your healthcare provider of all medications you currently use, including any herbal supplements. Due to the vasodilatory effects of Stendra, individuals with uncontrolled severe hypotension ($\textBP < 90/50 \text mmHg$) or recent cardiovascular events (such as stroke or Heart Attack within the last six months) must exercise extreme caution. Always discuss your history of non-arteritic anterior ischemic optic neuropathy ($\textNAION$) or inherited retinal disorders with your clinician.

Drug Interactions

Combining Stendra with certain medications can alter drug levels in your blood, increasing adverse effects.

Potential Side Effects

Common Side Effects

These effects are usually mild and tend to diminish as your body adjusts to the medication:

• Headache
• Flushing (redness or warmth in the face/neck)
• Nasal congestion or runny nose
• Back Pain or muscle aches

Less Common Side Effects

These side effects are reported less frequently but still warrant monitoring:

• Dyspepsia (indigestion or heartburn)
• Fatigue or tiredness
• Blurred vision

Serious Side Effects

If you experience any of the following, seek immediate medical attention:

• Vision loss in one or both eyes ($\textNAION$).
• Sudden hearing impairment or loss.
• An erection lasting longer than four hours (priapism).
• Signs of an allergic reaction (swelling, difficulty breathing).

Who Should Avoid This Medication?

Stendra is contraindicated (should not be used) in specific medical situations due to safety concerns.

• Individuals taking any form of nitrate medication for chest Pain, such as nitroglycerin.
• Patients with known hypersensitivity or allergy to Avanafil or any component of the pill.
• Individuals with severe pre-existing cardiovascular conditions limiting sexual activity.
• Those with uncontrolled, severe hepatic or renal impairment.
• Men who have experienced a stroke or myocardial infarction within the past six months.

Storage Instructions

Proper storage ensures the medication remains effective and safe for use.

• Store Stendra at controlled room temperature, typically between $15^\circ \mathrmC$ and $30^\circ \mathrmC$.
• Keep the medication in its original, tightly closed container to protect it from moisture.
• Store away from direct light and excessive heat.
• Ensure the medication is kept securely stored away from children and pets.

Stendra Alternatives

For erectile dysfunction treatment, alternative medications are available, primarily within the same drug class.

Frequently Asked Questions

How quickly does Stendra usually start working?

Stendra often begins to show its effect quite rapidly, typically within 15 to 30 minutes after administration under conditions of sexual arousal.

Does Stendra affect fertility or sperm quality?

Current clinical data do not indicate that Avanafil negatively impacts sperm count or motility in men being treated for $\textED$.

Can I take Stendra daily if I plan intimacy every day?

Stendra is generally formulated for on-demand use, with a maximum frequency of once per 24 hours. It is not typically intended for once-daily use like some other PDE5 inhibitors, unless specifically directed by a clinician for a certain dose.

Will Stendra interact with herbal remedies like Yohimbe?

Interactions between Avanafil and herbal remedies can be unpredictable; consult your healthcare provider before combining Stendra with any botanical supplements due to potential additive effects on blood pressure or heart rate.

Is a lower dose always necessary if I am over 65?

Dosage adjustments in older adults are often considered based on renal and hepatic function more so than age alone, but a lower starting dose is a common cautionary measure.

What if my erection lasts longer than four hours?

An erection exceeding four hours is a medical urgency called priapism and requires immediate evaluation at an emergency facility to prevent permanent tissue damage.

Glossary

$\textcGMP$ (cyclic Guanosine Monophosphate): A chemical messenger molecule in the penis that causes smooth muscle relaxation, leading to increased blood flow and erection. $\textPDE5$ Inhibitor (Phosphodiesterase Type 5 Inhibitor): A class of drugs that blocks an enzyme ($\textPDE5$), thereby increasing the levels of $\textcGMP$ to treat $\textED$ or Pulmonary Hypertension. Vasodilatation: The widening or opening of blood vessels, which increases blood flow to an area. Priapism: A painful erection lasting four hours or more, which is a medical emergency.

Disclaimer

This article provides general educational information about Stendra ($\textAvanafil$) for educational purposes only. This content is intended for informed adults seeking knowledge and does not substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare practitioner in the UAE or elsewhere. Information regarding off-label uses is purely for informational context and requires explicit consultation and authorization from your physician. Always seek the guidance of your doctor with any questions you may have regarding a medical condition or before starting, changing, or stopping any course of treatment. Availability and access to this medication are subject to local regulatory guidelines.