Baclofen
Baclofen is a skeletal muscle relaxant that acts on nerves in the spinal cord. It is used for certain forms of spasticity, including muscle stiffness and tightness associated with multiple sclerosis or spinal cord conditions.
Key points
- Baclofen acts centrally to reduce the number and severity of muscle spasms.
- Lioresal and Baclosign both contain baclofen alone.
- Each attached record represents 10 mg and 25 mg tablets.
- Sudden withdrawal can cause serious neurological symptoms.
A compact two-brand catalogue
Lioresal and Baclosign carry the same attached ingredient, tablet form and strength range. Both connect with spasticity and muscle spasms in the pain and anti-inflammatories category.
Their shared catalogue facts make this an ingredient-led page: brand name is the main visible difference in the attached data. No combination product or non-tablet form is represented here.
Spinal action and withdrawal
Baclofen reduces excitatory signalling in the spinal cord. This can ease stiffness, spasms and associated pain, but it can also cause drowsiness, weakness, dizziness or confusion.
Its withdrawal profile is especially important. Abruptly stopping baclofen after regular use can lead to fever, hallucinations, confusion, muscle rigidity or seizures. Official information therefore treats a gradual, clinically directed change as part of safe medicine handling rather than a generic precaution.
Further reading
Related articles

28 Jul 2026 ⋅ 8 min read
Baclofen: What It Treats, the Drowsiness, and Why You Never Stop It Suddenly
Baclofen is a muscle relaxant for spasticity, most often from multiple sclerosis. Drowsiness affected up to 63% of people in trials, and hallucinations and seizures have occurred on abrupt withdrawal.
Read guide