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Valparin

Valproic Acid

Indicated to address neural hyperexcitability to manage seizure activity and support mood stabilisation.

Active ingredient
Valproic Acid
Route
Oral use
Form
Tablet
Strengths
250mg · 500mg · 750mg

Prescription and consultation requirements for Valparin vary by destination and are determined by the fulfilment partner.

Valparin details

Alternative names
valproate
Therapeutic class
Anticonvulsant
Pharmacological class
Antiepileptic Agent
Known off-label uses
migraine prophylaxis
Minor side effects
nausea; somnolence; dizziness
Moderate side effects
weight gain; thrombocytopenia; alopecia
Dosage forms
Tablet
Administration route
Oral use
Supply category
Prescription-only medicine (POM)
Manufacturer
Sanofi-Aventis
Onset Time
1–2 weeks
Duration
12–24 hours
Storage instructions
Store below 25°C.
Drug interactions
Aspirin; Lamotrigine; Carbamazepine
Age restrictions
Approved for children, adolescents, and adults.
Contraindications

active hepatic disease; mitochondrial disorders (POLG mutation); pregnancy (for migraine prophylaxis)

Serious side effects

severe hepatotoxicity, requires immediate medical attention; acute pancreatitis, requires immediate medical attention; suicidal ideation, requires immediate medical attention

Patient summary

indicated to address neural hyperexcitability to manage seizure activity and support mood stabilisation.

Mechanism of action

Increases GABA concentration in brain synapses, blocking repetitive high-frequency neuronal firing and reducing excitability.

Pregnancy and breastfeeding

TGA Category D/X: High risk of congenital malformations and cognitive impairment. Avoid in pregnancy. Breastfeeding: Caution advised.