Samsca
Developed to mitigate severe water overload to support systemic sodium concentration levels and target fluid volume control.
- Category
- Hormone Therapy
- Active ingredient
- Tolvaptan
- Route
- Oral use
- Form
- Tablet
- Strengths
- 15mg
You will receive a quality generic equivalent of Samsca, depending on stock.
Prescription and consultation requirements for Samsca vary by destination and are determined by the fulfilment partner.
Samsca details
- Conditions
- Hypervolaemic Hyponatraemia · Euvolaemic Hyponatraemia
- Alternative names
- tolvaptan
- Therapeutic class
- Selective Vasopressin V2 Receptor Antagonist
- Pharmacological class
- Vasopressin Antagonist
- Known off-label uses
- autosomal dominant polycystic kidney disease
- Minor side effects
- dry mouth; thirst; polyuria
- Moderate side effects
- pollakiuria; hyperglycaemia; constipation
- Dosage forms
- Tablet
- Administration route
- Oral use
- Supply category
- Prescription-only medicine (POM)
- Originator
- Otsuka Pharmaceutical
- Onset Time
- 2–4 hours
- Duration
- 24 hours
- Storage instructions
- Store below 25°C.
- Drug interactions
- Ketoconazole; Clarithromycin; Grapefruit
- Age restrictions
- Approved for adults.
- Pregnancy and breastfeeding
- TGA Category C: Use if potential benefits outweigh risks. Breastfeeding: Avoid.
Contraindications
urgent need to raise serum sodium; inability to sense or respond to thirst; hypovolaemic hyponatraemia
Serious side effects
osmotic demyelination syndrome, requires immediate medical attention; severe hepatotoxicity, requires immediate medical attention
Patient summary
developed to mitigate severe water overload to support systemic sodium concentration levels and target fluid volume control.
Mechanism of action
Antagonises renal V2 receptors, preventing water reabsorption to promote excretion of free water without electrolyte loss.
What you will receive
Samsca is the originator brand name, made by Otsuka Pharmaceutical. We use it to identify the medicine and are not affiliated with Otsuka Pharmaceutical.
- The fulfilment partner confirms whether the exact brand or an equivalent containing Tolvaptan is offered.
- The offered brand, manufacturer and dispatch location depend on the product, destination and partner warehouse.
- Check the final product details at checkout before confirming an order.