Zytanix
Indicated to address severe fluid retention to manage peripheral oedema and alleviate cardiovascular strain.
- Category
- Heart & Blood Pressure
- Active ingredient
- Metolazone
- Route
- Oral use
- Form
- Tablet
- Strengths
- 2.5mg
Prescription and consultation requirements for Zytanix vary by destination and are determined by the fulfilment partner.
Zytanix details
- Alternative names
- metolazone
- Therapeutic class
- Thiazide-like Diuretic
- Pharmacological class
- Diuretic
- Known off-label uses
- nephrotic syndrome-associated oedema
- Contraindications
- anuria; severe hepatic coma; severe electrolyte depletion; sulfonamide allergy
- Minor side effects
- dizziness; nausea; headache
- Moderate side effects
- hypokalaemia; orthostatic hypotension; hyperuricaemia
- Dosage forms
- Tablet
- Administration route
- Oral use
- Supply category
- Prescription-only medicine (POM)
- Manufacturer
- Zydus Cadila
- Onset Time
- 1–2 hours
- Duration
- 12–24 hours
- Storage instructions
- Store below 25°C.
- Drug interactions
- Lithium; Digoxin; Furosemide
- Age restrictions
- Approved for adults.
Serious side effects
severe hypokalaemia, requires immediate medical attention; acute pancreatitis, requires immediate medical attention
Patient summary
indicated to address severe fluid retention to manage peripheral oedema and alleviate cardiovascular strain.
Mechanism of action
Blocks active sodium reabsorption in the distal tubules, inducing renal clearance of water and salt.
Pregnancy and breastfeeding
TGA Category B: Safety established. May contract maternal fluid volume. Breastfeeding: Expelled in low amounts.