Istamet

Formulated to target type 2 diabetes mellitus to support glycaemic control.

Dosage

Pack size

Category: Diabetes Management
Active ingredients: Sitagliptin · Metformin
Route: Oral use
Form: Film-coated tablet
Strengths: 50mg + 1000mg

Prescription and consultation requirements for Istamet vary by destination and are determined by the fulfilment partner.

Istamet details

Condition: Type 2 Diabetes Mellitus
Alternative names: Janumet
Therapeutic class: Dipeptidyl Peptidase-4 (DPP-4) Inhibitor; Biguanide Antidiabetic
Pharmacological class: DPP-4 Inhibitor; Biguanide
Minor side effects: nausea; diarrhoea; headache
Moderate side effects: upper respiratory tract infection; nasopharyngitis
Dosage forms: Film-coated tablet
Administration route: Oral use
Patient summary: formulated to target type 2 diabetes mellitus to support glycaemic control.
Supply category: Prescription-only medicine (POM)
Manufacturer: Merck Sharp & Dohme
Onset Time: 1–2 hours
Duration: 12–24 hours
Storage instructions: Store below 25°C, away from sunlight and moisture.
Drug interactions: Alcohol; Iodinated contrast media
Age restrictions: Not indicated for use in children or adolescents.

Contraindications

hypersensitivity to sitagliptin; hypersensitivity to metformin; severe renal impairment; diabetic ketoacidosis; severe hepatic impairment

Precautions and warnings

monitor renal function regularly; risk of lactic acidosis; discontinue if symptoms of pancreatitis occur

Serious side effects

pancreatitis, requires immediate medical attention; lactic acidosis, requires immediate medical attention; anaphylaxis, requires immediate medical attention

Mechanism of action

This medicine combines two active agents that work by increasing incretin levels to stimulate insulin release after meals and by reducing glucose production in the liver, effectively lowering blood sugar levels.

Pregnancy and breastfeeding

Pregnancy: should be avoided unless clearly necessary. Breastfeeding: not recommended as components may pass into breast milk.