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Major Depressive Disorder

Major depressive disorder is a persistent form of depression that lasts for weeks or months rather than a few days. It can affect the way a person feels, thinks and manages everyday life.

Zoloft

Sertraline

25mg · 50mg · 100mg

Sertraline tablets for major depressive disorder and panic disorder. It is an SSRI that can take a few weeks to show its full effect.

From$0.32/ tabletView

Lexapro

Escitalopram

5mg · 10mg · 20mg

Escitalopram tablets for depression and generalised anxiety disorder. It boosts serotonin levels in the brain, helping stabilise mood.

From$0.49/ tabletView

Fluoxetine Capsules

Fluoxetine

10mg · 20mg

Fluoxetine capsules for depression and obsessive-compulsive disorder. It increases serotonin in the brain to regulate mood.

From$0.44/ capsuleView

Pristiq

Desvenlafaxine

50mg · 100mg

Desvenlafaxine tablets for major depressive disorder. It raises both serotonin and norepinephrine, making it different from SSRIs that target one.

From$1.07/ tabletView

Cymbalta

Duloxetine

20mg · 30mg · 40mg · 60mg

Duloxetine capsules for depression and diabetic nerve pain. The coating stops the medicine releasing in the stomach.

From$1.05/ capsuleView

Effexor Xr

Venlafaxine

37.5mg · 75mg · 150mg

Venlafaxine capsules for depression and generalised anxiety. They raise both serotonin and noradrenaline, a broader action than SSRIs.

From$1.07/ capsuleView

Seroquel

Quetiapine

25mg · 50mg · 100mg · 200mg · 300mg

Quetiapine tablets for schizophrenia and bipolar disorder. It rebalances dopamine and serotonin to stabilise mood and reduce psychosis.

From$0.47/ tabletView

Endep

Amitriptyline

10mg · 25mg · 50mg · 75mg

Amitriptyline tablets for depression and nerve pain. They are often given at a lower dose for pain than for mood.

From$0.46/ tabletView

Elavil

Amitriptyline

10mg · 25mg · 50mg · 75mg

Amitriptyline tablets for major depressive disorder. They belong to an older class of antidepressants that can also be sedating.

From$0.60/ tabletView

Remeron

Mirtazapine

7.5mg · 15mg · 30mg

Mirtazapine tablets for major depression. They boost two mood-regulating chemicals in the brain.

From$1.32/ tabletView

Paxil

Paroxetine

10mg · 20mg · 30mg · 40mg

Paroxetine tablets for major depressive disorder and panic disorder. It stops the brain reabsorbing serotonin, leaving more to act.

From$0.97/ tabletView

Celexa

Citalopram

10mg · 20mg

Citalopram tablets for major depressive disorder. It can take several weeks to reach its full effect, so it is not a quick solution for symptoms.

From$0.99/ tabletView

Abilify

Aripiprazole

5mg · 10mg · 15mg · 20mg

Aripiprazole tablets for schizophrenia and bipolar disorder. It balances brain chemicals without the heavy sedation older antipsychotics cause.

From$0.90/ tabletView

Trintellix

Vortioxetine

10mg

Vortioxetine tablets for major depressive disorder. It targets serotonin reuptake and receptors to help balance mood.

From$1.79/ tabletView

Viibryd

Vilazodone

20mg · 40mg

Vilazodone tablets for major depressive disorder. It boosts serotonin while also partially activating a receptor that helps mood.

From$1.64/ tabletView

Desyrel

Trazodone

25mg · 50mg · 100mg

Trazodone tablets for major depressive disorder. It enhances mood-regulating brain chemicals by blocking serotonin reuptake and calming overactive receptors.

From$0.83/ tabletView

Pamelor

Nortriptyline

25mg

Nortriptyline capsules for major depressive disorder. It raises norepinephrine levels in the brain to help stabilise mood.

From$0.85/ capsuleView

Sinequan

Doxepin

10mg · 25mg · 75mg

Doxepin capsules for depression and generalised anxiety. This tricyclic antidepressant also tends to be sedating.

From$0.88/ capsuleView

Anafranil

Clomipramine

10mg · 25mg · 50mg · 75mg

Clomipramine capsules for obsessive-compulsive disorder and depression. It tends to cause more drowsiness than other antidepressants in its class.

From$1.01/ capsuleView

Prothiaden

Dosulepin

50mg · 75mg

Dosulepin tablets for major depression. They keep mood chemicals in the brain for longer.

From$0.91/ tabletView

Venlor

Venlafaxine

75mg

Venlafaxine tablets for depression and generalised anxiety. It boosts the brain's serotonin and noradrenaline levels.

From$1.19/ tabletView

Asendin

Amoxapine

50mg · 100mg

Amoxapine tablets for depression. It is related to the antipsychotic loxapine, which gives it a slightly different profile from other antidepressants.

From$1.86/ tabletView

Emsam

Selegiline

5mg

Selegiline transdermal patch for major depressive disorder. Because it is a patch, the medicine is absorbed gradually through the skin.

From$2.42/ tabletView

Tynept

Tianeptine

12.5mg

Tianeptine tablets for major depressive disorder. It works differently from most antidepressants by boosting serotonin reuptake rather than blocking it.

From$4.95/ tabletView

Tofranil

Imipramine

25mg · 50mg · 75mg

Imipramine tablets for depression and bedwetting in children. It balances mood chemicals in the brain.

From$0.92/ tabletView

Key points

  • Depression is a real illness with real symptoms, not a personal weakness or a state someone can simply shake off.
  • Symptoms can vary in severity and may include persistent sadness, loss of interest, hopelessness or anxiety.
  • Several factors may play a part, including genetic, biological, environmental and psychological factors.
  • Treatment is matched to severity and can include lifestyle changes, talking therapies and medicines.

Medicines listed for Major Depressive Disorder

The listed products span several classes of antidepressants used in managing depression, including selective serotonin reuptake inhibitors, serotonin and noradrenaline reuptake inhibitors, and older tricyclic antidepressants. They include Sertraline and Venlafaxine. Their active ingredients and product forms vary across the catalogue.

Further reading