Sitagliptin Tablets
Inhibits DPP-4 to enhance incretin hormones, improving glycaemic control in type 2 diabetes mellitus by increasing insulin secretion and decreasing glucagon in a glucose-dependent manner.
- Category
- Diabetes Management
- Active ingredient
- Sitagliptin
- Route
- Oral use
- Form
- Film-coated tablet
- Strengths
- 50mg · 100mg
The exact manufacturer offered is confirmed by the fulfilment partner before supply.
Prescription and consultation requirements for Sitagliptin Tablets vary by destination and are determined by the fulfilment partner.
Sitagliptin Tablets details
- Conditions
- Improve Glycaemic Control in Adult Patients with Type 2 Diabetes Mellitus as Monotherapy When Metformin Is Inappropriate Due to Contraindications or Intolerance · Improve Glycaemic Control in Adult Patients with Type 2 Diabetes Mellitus as Dual Oral Therapy in Combination with Metformin · Improve Glycaemic Control in Adult Patients with Type 2 Diabetes Mellitus as Dual Oral Therapy in Combination with A Sulphonylurea · Improve Glycaemic Control in Adult Patients with Type 2 Diabetes Mellitus as Dual Oral Therapy in Combination with A Thiazolidinedione · Improve Glycaemic Control in Adult Patients with Type 2 Diabetes Mellitus as Triple Oral Therapy in Combination with A Sulphonylurea and Metformin · Improve Glycaemic Control in Adult Patients with Type 2 Diabetes Mellitus as Triple Oral Therapy in Combination with A Thiazolidinedione and Metformin · Improve Glycaemic Control in Adult Patients with Type 2 Diabetes Mellitus as Add-on to Insulin with or Without Metformin
- Alternative names
- Januvia
- Therapeutic class
- Drugs used in diabetes
- Pharmacological class
- Dipeptidyl peptidase 4 (DPP-4) inhibitor
- Contraindications
- hypersensitivity to sitagliptin or any excipients
- Moderate side effects
- arthralgia; constipation; dizziness; peripheral oedema
- Dosage forms
- Film-coated tablet
- Administration route
- Oral use
- Supply category
- Prescription-only medicine (POM)
- Originator
- Merck Sharp & Dohme (UK) Limited
- Storage instructions
- This medicinal product does not require any special storage conditions.
- Drug interactions
- sulphonylureas; insulin; digoxin
- Age restrictions
- Not recommended for children and adolescents under 18 years.
Precautions and warnings
should not be used in patients with type 1 diabetes or for treatment of diabetic ketoacidosis; risk of acute pancreatitis; discontinue if pancreatitis is suspected; dose reduction in moderate to severe renal impairment; caution in patients with a history of pancreatitis; risk of hypoglycaemia when used with sulphonylurea or insulin
Minor side effects
headache; nasopharyngitis; upper respiratory tract infection; hypoglycaemia; nausea
Serious side effects
acute pancreatitis, requires immediate medical attention; stevens-Johnson syndrome, requires immediate medical attention; angioedema, requires immediate medical attention; anaphylaxis, requires immediate medical attention
Patient summary
Inhibits DPP-4 to enhance incretin hormones, improving glycaemic control in type 2 diabetes mellitus by increasing insulin secretion and decreasing glucagon in a glucose-dependent manner.
Mechanism of action
Sitagliptin belongs to a class of medicines called DPP-4 inhibitors. It works by increasing the levels of natural substances called incretins, which help the body produce more insulin when blood sugar is high and reduce the amount of sugar made by the liver. This helps to control blood sugar levels in adults with type 2 diabetes. Sitagliptin is used when diet and exercise alone are not sufficient to control blood glucose.
Pregnancy and breastfeeding
Should not be used during pregnancy unless clearly necessary. No adequate data from use in pregnant women. Animal studies do not indicate direct or indirect harmful effects.
What you will receive
Sitagliptin Tablets is a generic medicine sold under the name of its active ingredient, Sitagliptin, rather than under a brand.
- The fulfilment partner confirms the offered manufacturer and product before supply.
- Check the active ingredient, strength, form and pack shown at checkout before confirming an order.