Frumil
Amiloride and furosemide tablets for oedema and fluid build-up from liver cirrhosis. Furosemide clears fluid, amiloride holds on to potassium.
- Category
- Heart & Blood Pressure
- Active ingredients
- Amiloride · Furosemide
- Route
- Oral use
- Form
- Tablet
- Strengths
- 5mg + 40mg
Prescription and consultation requirements for Frumil vary by destination and are determined by the fulfilment partner.
Frumil details
- Conditions
- Oedema · Hepatic Cirrhosis-associated Ascites
- Alternative names
- amiloride, furosemide
- Therapeutic class
- Loop Diuretic, Potassium-Sparing Diuretic Combination
- Pharmacological class
- Diuretic Combination
- Contraindications
- anuria; hyperkalaemia; severe renal failure; addison's disease
- Minor side effects
- nausea; dizziness; headache
- Moderate side effects
- electrolyte depletion; orthostatic hypotension; muscle cramps
- Dosage forms
- Tablet
- Administration route
- Oral use
- Supply category
- Prescription-only medicine (POM)
- Manufacturer
- Sanofi
- Onset Time
- 1 hour
- Duration
- 6–8 hours
- Storage instructions
- Store below 25°C.
- Drug interactions
- Lithium; Digoxin; Potassium Supplements
- Age restrictions
- Approved for adults.
Serious side effects
severe hyperkalaemia, requires immediate medical attention; aplastic anaemia, requires immediate medical attention
Patient summary
Amiloride and furosemide tablets for oedema and fluid build-up from liver cirrhosis. Furosemide clears fluid, amiloride holds on to potassium.
Mechanism of action
Furosemide induces rapid sodium and water clearance in loop of Henle, while amiloride conserves potassium in distal tubules.
Pregnancy and breastfeeding
Pregnancy: Avoid in pregnancy due to risk of placental hypoperfusion. Breastfeeding: Avoid.